MMP gelten nie als alleinige Ursache FC-induzierter Gewebeschäden.
Klar ist bislang vor allem, dass Gewebeschäden durch FC auf Nekrosen beruhen:
"In one patient who had a rupture, the histopathology showed necrosis... Histopathology in a second case of ruptured Achilles tendon showed
necrosis..."
https://www.fqresearch.org/pdf_files/103.pdf"extensive hepatocellular
necrosis"
https://www.ncbi.nlm.nih.gov/pubmed/14994731"acute tubular
necrosis"
https://www.ncbi.nlm.nih.gov/pubmed/18614979http://ekjm.org/journal/view.php?number=24917"hepatocyte necrosis, acute tubular
necrosis"
https://jamanetwork.com/journals/jamade ... act/480883"full-thickness epidermal
necrosis"
https://pdfs.semanticscholar.org/3293/a ... ecdee7.pdf"Chondrocyte
toxicity and necrosis"
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC164164/"single-cell
necrosis, coagulative
necrosis"
https://pharmacologia.com/fulltext/?doi ... 12.477.480"phototoxic reaction that included
necrosis"
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2910230/Die Nekrose beruht auf direkten Zellschäden:
"Necrosis results from direct damage to the cells primarily leading to cell membrane leakage and subsequent cell death..."
(
http://onlinelibrary.wiley.com/doi/10.1 ... 425045/pdf)
Das korreliert mit der Einschätzung einiger Autoren, dass es sich bei FC-Schäden um direkte toxische Wirkungen handeln könnte (steht bereits im Forum):
"The sudden onset of some tendinopathies, occasionally after a single dose of a fluoroquinolone,
suggests a direct toxic effect on collagen fibers."
(
http://databankws.lareb.nl/Downloads/ACR2001_920.pdf)
"There may be a
direct toxic effect on the collagen. The sudden onset of some tenopathies, sometimes after a single dose of a quinolone, suggests the possibility of
direct toxicity."
(
http://www.boneandjoint.org.uk/content/ ... 3.full.pdf)
"Although the pathoetiology is certainly multifactorial, alterations in cell signaling proteins and direct toxic effects on musculoskeletal tissues have been strongly implicated."
(
https://www.ncbi.nlm.nih.gov/pubmed/21333952)
"However, it is possible that FQs have a
direct cytotoxic effect on enzymes found in mammalian musculoskeletal tissue... FQs have chelating properties against several metal ions (e.g., calcium, magnesium, aluminum), and have been known to cause
direct toxicity to type 1 collagen synthesis and promote collagen degradation... Chondrocyte depletion and fissures on adjacent nonruptured tendons are also suggestive of
direct toxicity related to FQ exposure."
(
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2921747/)