Fluorchinolone-Nebenwirkungen

Hallo,

ein direktes Testverfahren, welches rechtsverbindlich beweisen könnte, dass Fluorchinolone den menschlichen Stoffwechselprozess langfristig / persistent negativ beeinflussen gibt es leider nicht. Allerdings gibt es diverse Testverfahren, welche unter „Flox“ darstellbar abweichende Werte von Stoffwechselprozessen im Bezug zu gesunden Menschen zeigen.
Theoretisch scheint bei Gefloxten Menschen bekannt zu sein, dass :

1. Die intrazelluläre Magnesiumversorgung stark reduziert wird
2. Der Gluthationspiegel (Schutz vor Oxidativem Zellstress / Entgiftungsprozesse) erniedrigt ist
3. Ein erhöhter Oxidativer Zellstress besteht (Zunahme Matrix-Metalloproteasen etc.)
4. Enzyme und Hormone beeinflusst werden (z.B. CYP 450 etc.)

Daher möchte ich diverse Testmöglichkeiten mit Informationen in diesem Thema sammeln.
Eine gute Basis an verschiedenen Testmöglichkeiten bietet das Labor: http://www.ganzimmun.de
Die meisten Tests können leider nur in Eigenleistung, ohne Kassenärztliche Übernahme gemacht werden. Man sollte es aber stets über den Hausarzt / Facharzt versuchen. Sofern man es privat übernimmt sollte man die Test den Medizinern auf jeden Fall zur Verfügung stellen und die Ergebnisse diskutieren.

Test-Nr. 7208 Organix-Neuro inkl. Kynurenin-Tryptophan-Ratio (ca. 114 Euro) ->
Der Tryptophanstoffwechsel ist bei Flox vermutlich gestört -> Joseph King Studie + div. eigene Erfahrung siehe Thema viewtopic.php?f=70&t=282

Test-Nr 7207 Organix-Citronensäurezyklustest (ca. 75 Euro) ->
Die Mitochondriale Atmungskette, zeigt wie es um deinen Mito-Stoffwechsel aussieht

Test-Nr 8527 ATP-Blockade (87 Euro) ->
Details in PDF-Datei anbei. Einige Gefloxte haben diesen Test mehrfach gemacht, um ihr deutlich erniedrigtes ATP Profil über einen Zeitraum zu monitoren. Das ATP gilt als Energieleistung der Mitochondrien zwecks Zellbildung.

Test-Nr. 6230 Nitrostress-Urintest (71 Euro)->
Status Oxidativer Zellstreß. Methylmalonsäure als Indikator für Vitamin B12 Versorgung.

Sinnvoll Tests zwecks kontrollierte Strategie von Nahrungsergänzungsmitteln (NEM):

Test-5319 Mikronährstoff-Profil (79 Euro)
Ca, Fe, K, Cu, Mg, Mn, Mo, Se, Zn, kleines Blutbild, Vitamin B6

Test-Nr 5354 - Vitamin D (21 Euro) -> Produktempfehlung nutze ich selbst:
https://www.amazon.de/Vitamin-Unabh%C3% ... B0179XD9VW

Test-Nr 7223 - Q10 (23 Euro) -> Produktempfehlung nutze ich selbst:
https://www.amazon.de/MitoQ%C2%AE-Mitoq ... ords=mitoq

https://www.amazon.de/Premium-Ubiquinol ... inol&psc=1
(enthält zudem Vit C + Vit E daher optimal)


Mit den folgenden sechs Markern kann man den Pathomechanismus
von chronischen Multisystemerkrankungen (CMI = Chronic Multisystem Illnesses) abklären:

Quelle: Artikel - Umweltmedizin 2013 – eine Bilanz nach 20 Jahren

- TNF-alpha => Entzündung
- IP-10 => TH1-Aktivierung
- ATP intrazellulär => Mitochodriopathie
- Histamin => Mastzell induzierte Entzündung
- MDA-LDL => oxidativer Stress
- freies 3-Nitrotyrosin => nitrosativer Stress.

Gruß Schorsch

Joseph King Studie

Gene Sequencing


The following gene mutations and fractures where found in the following six individuals as results from the Fluoroquinolone DNA-adducts:

CYP - Cytochrome P450 family and subgroups.4 Responsible for the metabolism of many drugs and environmental chemicals that it oxidizes and neutralizes

NAT - N-acetyltransferase NAT1, NAT2. The NAT acetylation polymorphism is important because of its primary role in the activation and/or deactivation of many chemicals in the body's environment, including those produced by cigarettes as well as aromatic amine and hydrazine drugs used medicinally. In turn, this can affect an individual'cancer risk.

GAD - Glutamic Acid Decarboxylase, GAD1, Neuropathy and Stiff-Persons-Syndrome

MTHFR, Protein-C deficiency resulting in later-onset neurodegenerative disorders

PRTN, PRTN3, PR-3 Proteinase/Proteinase-3Polymorphonuclear - leukocyte serine protease that
degrades elastin, fibronectin, laminin, vitronectin, and collagen types I, III, and IV [connective tissue -
muscular/skeletal complications]

COMT - Catechol-O-methyltransferase, Catalyzes the transfer of a methyl group from Sadenosylmethionine
to catecholamines, including the neurotransmitters dopamine, epinephrine, and
norepinephrine.

3 Genotoxic and cytotoxic effects of antibacterial drug, ciprofloxacin, on human lymphocytes in vitro
PS Ambulkar,1 SK Ghosh,2 IV Ingole3 and AK Pal3
1 Department of Biotechnology,Agnihotri College of Science, Wardha-442001, India, 2 Department of Anatomy, Nepal Medical College, Jorpati, Kathmandu, Nepal
3 Human Cytogenetics Unit, Department of Anatomy, Mahatma Gandhi Institute of Medical Sciences, Sewagram, Wardha – 442102, India.
4 Seven subgroups from the CYP-P450 gene family were identified.

Bild 1. Ursache / Wirkungsübersicht von Defiziten und Mikronährstoffen

Bild 2. Weitere Testmöglichkeiten aus Floxreport

Quell: http://www.myquinstory.info/what-helps/#tests


Priorität medizinischer Tests unter Flox, siehe auch Infolink / Quelle:


TESTS:
All medical tests should be interpreted by a trusted health provider. The ability for floxies to obtain tests varies via individual situations. Some floxies have the ability to obtain necessary medical care, while others have limited means and thus limited access to testing. Because of this, where applicable, I have listed by each test information on each test and a link to a lab for low cost testing. Lab tests can vary tremendously in their price between labs. I occasionally shop around to try and find the lowest cost, on average. Obviously, no one is under any obligation to use this information, it is just provided as a service to those who wish to use it. If any monies are generated from low cost lab affiliate links, it is donated to FQ research, I never personally profit. Read my monetization policy here.
A description of some of the more common test abnormalities seen on each test, anecdotally observed and shared by floxies, is listed in the section directly below this section.

(highest priority first:)
• comprehensive metabolic panel, and urinalysis. (info)(lab1)(lab2)
• 25-hydroxy vitamin D.(info)(lab)
• C-reactive protein.(info)(lab)
• ESR/sedimentation rate/Westergren, and LDH.(info)(lab)
• ANA test.(info)(lab)
• rheumatoid factor.(info)(lab)
• serum ferritin.(info)(lab)
• total testosterone and free testosterone, in both men and women.(info)(lab)
• thyroid including TSH, T3, rT3, and T4.(info)(lab)
• CBC with differential, lymphocyte subpanel, complement tests, total IgG, immunoglobulin G subclasses 1-4, extractable nuclear antigens, serum and urine immunofixation tests.(info)
• vitamin B12 and B6.(info)
• progesterone, in women.
• serum magnesium.(info)
• MRI of joints can’t walk on, if doctor agrees (MRIs tend to not show much unless joint pain is quite severe).
• EMG, NCS, skin punch biopsy nerve tests, if still having neuropathy at 3 months.
 
(medium priority:)
• fasting blood glucose and insulin; hemoglobin A1C.
• IGF-1, HGH.
• apolipoprotein A-1 (Apo A-1).
• cortisol.
• cholesterol.
• blood pressure and EKG, if heart rhythm is abnormal.
• vitamin B1, B3, B5, B9, if nerve pain still present at 3 months.
• brain MRI and quantitative EEG, if CNS symptoms are debilitating and last > 2 months.
• abdominal ultrasound (look for liver, kidney, spleen, ovarian lesions/cysts).

(low priority:)
• gastric emptying study.
• endoscopy.
• oral glucose tolerance test with 75 grams glucose measuring glucose and insulin for four hours (if tolerant of some sugar), if no neuropathy improvement in 6 months.

Your doctor may also want to rule out rheumatoid arthritis, lupus, drug-induced lupus (anti-histone antibody test), Lyme disease, Sjörgren’s syndrome, multiple sclerosis, fibromyalgia, mixed connective tissue disease, polymyositis, neuromyotonia (NMT, aka Isaac’s syndrome), and erythromelalgia depending on your symptoms.
If experiencing excessive bruising or dark blue spots under skin of limbs (petechiae or purpura), ask your doctor if prothrombin time (PT) and partial thromboplastin time (APTT) tests are advised.
For neuropathy, nerve tests of nerve conduction studies that check demyelination of muscle control nerves and electromyography (EMG) that measures muscles and nerve-muscle junctions may be abnormal in severe cases wherein reduced muscle output and muscle wasting are experienced. Skin punch biopsy to count damaged small fiber nerve axons is the most reliable test for FQ neuropathic pain, particularly with sensations of diffuse pain, burning, or buzzing. Unless severe and disabling, waiting 3 months before testing can increase likelihood of measurable damage on tests. In less severe cases, only the skin punch biopsy may be abnormal. Despite the usefulness of QSART in diagnosing peripheral neuropathy as reported in medical literature and the commonality of suffering changes in sweating response such as lack of sweating, no reports of test results have been shared thus far.
 
A description of some of the more common test abnormalities:
(highest priority tests:)
• Very many sufferers have low vitamin D, commonly with poor responsiveness to supplementation.
• C-reactive protein (CRP) and erythrocyte sedimentation rate (ESR) and lactate dehydrogenase (LDH) indicate inflammation or cell death and can justify musculoskeletal symptoms, with CRP most commonly being high during the early months.
• ANA tests are often abnormal with speckled pattern (indirect immunofluorescence microscopy) or high titer numbers (ELISA) reported, particularly in women.
Less commonly than for ANA, rheumatoid factor has also appeared high for several months.
• Ferritin has been found low in many sufferers including those who later developed fatigue.
• Low testosterone for men is very common (up to 50% affected), but also occurs in women; FQ testosterone effects appear in animal studies; low testosterone is pro-inflammatory.
• Thyroid markers are often lowered in men and women, and thyroid medications often need adjustment.
• Those who go on to develop neuropathy have often reported low vitamin B12 or B6, although a fraction (~10%) with neuropathy already have high vitamin B6 levels so that B vitamin supplementation exacerbates neuropathic pain.
• Complete blood counts with differential, lymphocyte subpanels, complement tests (CH50, C4, etc.), total IgG, and IgG subclass tests have often revealed abnormalities in counts of lymphocyte and CD cell types and abnormalities in ratios between IgG subclasses.
• A number of women have reported low progesterone.
• A number of sufferers have low magnesium for months.
• MRI tests have revealed tendon degeneration, cartilage degeneration, cysts, and labral tears, but many MRIs didn’t detect abnormalities unless pain was severe or range of motion was limited.

(medium priority tests:)
• FQs as a class can cause dysglycemias.
• High HGH or IGF-1 during the first six months has been reported by several of those with diffuse tendinopathy.
• Apolipoprotein A-1 has tested extremely high for a few.
• High cortisol in the first 2-3 months has been reported by a few.
• Several have reported elevations of cholesterol with respect to previous tests.
• Several of those with abnormal heart rhythm (cardiac arrhythmia) have found unstable high and low blood pressure as well as abnormal electrocardiogram (EKG) results.
• Several other B vitamin high/low abnormalities have been reported.
• Several of those left unable to work had permanent brain lesions or brain abnormalities revealed by MRI and or quantitative EEG that justified claims for Social Security disability benefits.
• Liver enlargement, liver lesions, kidney cysts, spleen enlargement, spleen lesions, kidney lesions, and ovarian cysts all have been reported several times each.

(low priority tests:)
• Gastric emptying studies have revealed delayed gastric emptying (gastroparesis) in several of those having neuropathy combined with constipation or slow motility.
• Endoscopy has revealed stomach inflammation in several of those with nausea, reflux, and extensive food tolerance problems.
• Four-hour long oral glucose tolerance tests (OGTT) using 75 grams of carbohydrates have revealed a variety of blood sugar abnormalities for several persons, such as reactive hypoglycemia and more.

FOR DOCTORS:
When talking to doctors, it might be useful to tell them what page numbers in the 2011 Physicians Desk Reference to cross reference for confirmation that your symptoms are known FQ side effects, hence the following table is provided:
Book: Physicians Desk Reference, 2011, 65th edition.
Drug trade name (Generic name): page numbers describing Tendon, CNS, PNS, Arthralgia, Myalgia, Ocular side effects.
Cipro (Ciprofloxacin): pp. 1957 & 1959, p. 1961, p. 1959, p. 1961, p. 1957, p. 1961.
Levaquin (Levofloxacin): pp. 2710 & 2718, p. 2710, p. 2710, p. 2711, p. 2711, p. 2717.