Re: Fluorchinolone und Cortison
Verfasst: 07.07.2019, 01:04
Bitte vorsicht mit Kortison, das fummelt in den Mt rum u. verstärkt die Aktivität von OXPHOS Komplex I, dem Komplex der neben Komplex III den ROS erzeugt.
Kortison regt dessen Aktivität an was jedoch wahrscheinlich auch zu mehr ROS führt.
"Accordingly, cortisol treatment of isolated mitochondria enhances respiratory chain efficiency (energy produced per oxygen consumed) and increases complex I–driven respiration, which is partially encoded by the mtDNA, in a mechanism that requires mitochondrial gene expression and protein synthesis"
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5901654/
https://www.sciencedirect.com/science/a ... 0062#f0015
Kortison regt dessen Aktivität an was jedoch wahrscheinlich auch zu mehr ROS führt.
"Accordingly, cortisol treatment of isolated mitochondria enhances respiratory chain efficiency (energy produced per oxygen consumed) and increases complex I–driven respiration, which is partially encoded by the mtDNA, in a mechanism that requires mitochondrial gene expression and protein synthesis"
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5901654/