Ich persönlich leide neben der üblichen FQ Symptome auch an Ataxie und einseitigem Fallschwindel. Die Symptome sind nur noch sehr leicht vorhanden, waren aber in der ersten Monaten postflox/postmetro massiv vorhanden. Mehrere HNO Besuche zeigten ein völlig intaktes Gleichgewichtsorgan, die neurologischen Untersuchungen- Unterberger Tretversuch/ Romberg Test waren anfangs auffällig)
Laut Blog-Recherche würden die neurotoxischen Symptome aufgrund einer langfristig gestörten Thiaminaufnahme nach Metronidazol persistieren. Betroffene behandeln sich erfolgreich mit hochdosiertem Thiamin und Magnesium.
Das ist insofern interessant, da auch hier die mitochondrialen Prozesse des Kleinhirns (daneben auch Stammhirn und Basalganglien) beeinträchtigt sind. Es käme anscheinend auch bei der Metronidazol Intoxikation zu flare ups.
Die Blogbetreiberin schrieb folgendes auf floxiehope:
metrogirlblogger August 29, 2017 at 6:30 am Reply
Hi, Reychop. I am interested to know your insight into DNA damage through metronidazole; I know a lot of people who believe they suffered DNA damage because of this drug. However, fluoroquinolones cause mitochondrial DNA damage completely on their own. This isn’t something Lisa or other floxies need to theorize–it’s been proven through multiple studies and even the FDA admitted it on an drug assessment document in 2013 (and yet they left it off of the official FDA label). They know fluoroquinolones cause systemic DNA damage and all it takes is one pill to trigger these affects. That’s why drugs like Cipro, Levaquin, Avelox and other “floxie” drugs have 5 black box warnings a piece.
I’m actually not a floxie–I suffered a serious adverse reaction to metronidazole in 2015. I’ve never taken a fluoroquinolone, but I’ve researched it a lot to gain better understanding into ADRs in general. The effects of these drugs are deadly and disabling on their own.
Now, back to metronidazole. I am curious to know your theories about this, if you’ve uncovered some medical literature about its DNA effects, because the research into metronidazole is quite limited. That being said, I know, as do many in our support group, that metronidazole is a serious neurotoxin. Again, we don’t need to guess–the medical literature is out there. The drug causes lesions to the back of the brain. These are mainly on the cerebellum, but can also affect the basal ganglia and brain stem. In fact the brain stem is the second-most hit region after the cerebellum. Also, the nerves can get damaged (peripheral neuropathy). Most metronidazole victims complain about:
*Altered mental state. Usually horrible, constant panic attacks, loss of emotional control, depression, crying spells, lowering of stress threshold, extreme insomnia, derealization, depersonalization.
* Motor control issues. Usually gait disturbance (ataxia), dysarthria, hand tremors, leg twitches, (rarely) nystagmus. Seizures can happen but they are quite rare for this.
* Peripheral neuropathy. Sometimes only in hands/feet–sometimes everywhere.
* Autonomic dysfunction. This is one medical literature is missing badly. This include dysphagia, respiratory issues, digestion issues (complete loss of appetite is a very common issue, where you take two bites of something and can’t eat anymore), heart rate/blood pressure issues, salivation issues (many people now have a white tongue/mouth due to salivation dysfunction), heat/cold intolerance, loss of equilibrium. Some of are people with the worst cases have been diagnosed with autonomic dysfunction.
* Neck pain, light/sound sensitivity, headaches and/or head pressure (usually at the back of the head but sometimes all over the head), severe brain fog, extreme weakness and fatigue.
The symptoms are usually worse in the mornings and slowly improve as the day continues.
Any of these sound familiar? It’s due to brain damage; there are case studies, systematic reviews and a warning on the FDA label (although the warning is grossly simplistic) that no one bothers to look at even when patients present with symptoms.
I am sorry you’re going through this–I truly am. It’s a nightmare I wouldn’t wish on anyone. Most people do recover from metronidazole toxicity–about 65%. Others improve (about 29%–I’m in this group). About 3% is unknown and the remaining 3% have permanent cognitive impairment.
I am hoping you make a full recovery–that is the most common result. And yes, I’m certain this will make you a better doctor. In fact, it has the opportunity to make you a great one because you now know this problem firsthand.
If you want to learn more about metronidazole, I do have a blog at:
http://www.metrogirlblog.wordepress.com. It’s a little outdated (no mention of ANS issues, that’s something that’s become more apparent in the last several months), but still some good information and links. And let me know about the information you have about metronidazole DNA damage–there are some people in our support group who are leaning towards this theory, and I’m sure they’d love to learn.