Treatment of the Fluoroquinolone Associated Disability - the pathobiochemical implications
Long term Fluoroquinolone Associated Disability (FQAD) after fluoroquinolone (FQ)
antibiotic therapy appears in recent years a significant medical and social problem, because
patients suffer for many years after prescribed antimicrobial FQ-treatment from tiredness,
concentration problems, neuropathies, tendinopathies and other symptoms. The knowledge
about the molecular activity of FQs in the cells remains unclear in many details. The effective
treatment of this chronic state remains difficult and not effective. The current paper reviews
the pathobiochemical properties of FQs, hints the directions for further research and reviews
the research concerning the proposed treatment of patients.
Based on the analysis of literature, the main directions of possible effective treatment of
FQAD are proposed: (A) reduction of the oxidative stress, (B) restoring reduced mitochondria
potential ∆Ψm, (C) supplementation of uni- and bivalent cations that are chelated by FQs and
probably ineffectively transported to the cell. (Caution must be paid to Fe and Cu because
they may generate Fenton reaction), (D) stimulating the mitochondrial proliferation, (E)
removing FQs permanently accumulated in the cells (if this phenomenon takes place), (F)
regulating the disturbed gene expression and enzyme activity.
http://downloads.hindawi.com/journals/o ... 023935.pdf
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